Description

PLEASE APPLY BY CLOSING DATE: Monday September 15th, 2025

Reporting to the SVP, Oncology Translational Research Oncology Research Unit,, the Head Oncology Translation Liaison Science Lead will play a key role in the Oncology Translational Research (OTR) team within GSK Oncology. The postholder will be responsible for leading a team of translational cancer biologists/immunologists ('Oncology Translation Liaison scientists') providing Oncology exploratory biomarker strategy expertise. A strong focus is on 'mechanism-based' multimodal approaches to identify targets and exploratory biomarkers to support the ORU, building on the concept of digital biological twins. Based on GSK proprietary and internally generated from patient derived models and clinical trial samples, the Oncology Translation Liaison Science team will identify new targets & exploratory predictive biomarkers, unravel resistance mechanisms and generate translational hypotheses that will inform on patients stratification to enhance treatment effect.

Key Responsibilities

• Manage a team of Oncology Translation Liaison scientists representing OTRO in multidisciplinary trial teams of GSK assets.
• Lead on OTR representation and participation in the full development of exploratory predictive biomarkers assays that will be derived from data obtained within the Translational Research Network (TRN) collaborations with Global centres of excellence.
• Provide strategic and expert input into digital Path AI based 'exploratory' biomarkers for trials, in close collaboration with Oncology Translational Medicine
• Provide contributions to future experimental plan with the Oncology Translational Research wet lab teams, based on a solid 'mechanistic' understanding of multiomic/multimodality translational data from the Translational Research Network
• Define the translational cancer strategy responsible for achieving the Oncology Translational Research mission and vision involving 'mechanism-based' multimodal approaches to identify targets and exploratory biomarkers to support the ORU.
• Contribute as part of the group organised by Global Regulatory Affairs (GRA) to help communicate new translational research strategies and exploratory biomarker assays (e.g. organoids and organoid-derived surrogate biomarkers) to FDA, EMA and other regulatory authorities.
• Partner with the SVP Oncology Translational Research to develop and execute the organizational scientific strategy, especially in deriving multimodal exploratory precision biomarkers for stratifying combination therapies, initially involving antibody drug conjugate combinations
• Lead intra- and inter-department cross-functional teams, working groups or workstreams in support of Oncology Translational Research initiatives.
• Lead and drive discovery of exploratory oncology biomarkers, aligning and building sustainable, effective business partnerships within GSK Oncology Clinical Development Leadership (especially the newly established Oncology Clinical Development early science team), Development Leadership (EDL/MDL), Oncology tumor team (OTT), Oncology Translational Medicine (OTM), AIML, Strategic Partnerships Leadership, Research Technologies Leadership, as well as with external partners and collaborators.
• Leading and managing external collaborations with research partners
• Prepare data presentations and writing governance proposals for support/development and expansion of OTR capabilities
• Provide oversight and identify data that may be worth considering patenting (intellectual property (IP) generation) as well as producing IP documents.
• Undertake the annual review and setting objectives for direct reports within the Oncology Translational Research team

This position requires an on-site presence a minimum of two days per week at GSK's R&D site in Stevenage/UK.

Basic Qualifications:

• PhD in a cancer discipline
• Significant training/experience in Oncology and Translational Research with prior record of delivering new biomarkers to antibody drug conjugate based clinical trials
• Significant experience in a senior leadership role in translational research within the Pharmaceutical industry
• Experience in communicating new translational research strategies and exploratory biomarker assays to FDA, EMA and other regulatory authorities.
• A track record of publishing in digital Path image analysis-based machine learning method as applied to whole-slide images
• Successful track record in leading exploratory biomarker research for antibody-drug conjugates and other modalities e.g. T cell engagers
• Experience in developing 'mechanism-based' multimodal approaches to identify targets and biomarkers
• Experience in working with external scientific experts and clinical key-opinion-leaders to position oncology translational research programs in a highly competitive business environment.
• Strong skills in managing multiple projects simultaneously with an ability to prioritize appropriately.
• Strong skills in coaching and mentoring demonstrated in industry setting.

• Preferred Qualifications: 
• Ability to tackle a wide range of projects and competent in internal and external engagements.
• Strong analytical skills and ability to ascertain salient points from large amount of information 
• Strong organizational skills, management and tracking of critical information in a coherent way
• Strong interpersonal, communication and cross-functional team engagement
• Demonstrates flexibility and ability to work well with ambiguity and in intense situations.
• Gravitas and experience to create a positive relationship with third parties
• Must be able to act independently; must have confidence to make strategic and tactical decisions and prioritize effectively 
• Ability to escalate potential concerns or risks regarding partnerships to leadership 
• Proactive mindset that bridges ideas to realizable and deliverable solutions, and can help move both internal and external stakeholders to quickly solve problems
• Proven ability to navigate multi-faceted organizations with repeated success; tenacity and resourcefulness, routinely capable of displaying a measured, proportionate and calm approach under pressure

Why GSK?
Uniting science, technology and talent to get ahead of disease together.

GSK is a global biopharma company with a purpose to unite science, technology and talent to get ahead of disease together. We aim to positively impact the health of 2.5 billion people by the end of the decade, as a successful, growing company where people can thrive. We get ahead of disease by preventing and treating it with innovation in specialty medicines and vaccines. We focus on four therapeutic areas: respiratory, immunology and inflammation; oncology; HIV; and infectious diseases to impact health at scale.

People and patients around the world count on the medicines and vaccines we make, so we're committed to creating an environment where our people can thrive and focus on what matters most. Our culture of being ambitious for patients, accountable for impact and doing the right thing is the foundation for how, together, we deliver for patients, shareholders and our people.

GSK is an Equal Opportunity Employer. This ensures that all qualified applicants will receive equal consideration for employment without regard to race, color, religion, sex (including pregnancy, gender identity, and sexual orientation), parental status, national origin, age, disability, genetic information (including family medical history), military service or any basis prohibited under federal, state or local law.

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